Q) How long does it take to take a treatment?
A) It takes 30 minutes for anesthesia before a treatment and a treatment takes 10 to 15 minutes. For aftercare, it takes 15 minutes. Totally, INTRAcel treatment consumes approximately one hour.
2010년 7월 8일 목요일
Q) Treatment interval [INTRAcel,jeisys]
Q) Treatment interval
A) The interval between the first and second treatment must be over 35 days, the one between the second and third must be over 40 days. Because it takes about four weeks for the skin to be recovered from the treatment, the second treatment must be done after the skin fully regenerates. If second treatment was done within a month, recovery can be longer than usual.
A) The interval between the first and second treatment must be over 35 days, the one between the second and third must be over 40 days. Because it takes about four weeks for the skin to be recovered from the treatment, the second treatment must be done after the skin fully regenerates. If second treatment was done within a month, recovery can be longer than usual.
Q) Is anesthetic needed to be applied? Is it painful? [INTRAcel,jeisys]
Q) Is anesthetic needed to be applied? Is it painful?
A) It is not painful up to Level 3 using 0.8mm needle, but if it is over the level, it could be better to apply anesthetic on a person who receives a treatment. A pain depends on a person who receives a treatment, but it is thought to be less painful rather than the pain caused by fractional CO2 laser.
A) It is not painful up to Level 3 using 0.8mm needle, but if it is over the level, it could be better to apply anesthetic on a person who receives a treatment. A pain depends on a person who receives a treatment, but it is thought to be less painful rather than the pain caused by fractional CO2 laser.
Q) Can INTRAcel be used with a Botox or filler?
Q) Can INTRAcel be used with a Botox or filler?
A)Filler
It has no harm to inject a filler after treatment using INTRAcel, however, it can be harmful to take INTRAcel treatment after injecting a filler. Therefore it is recommended not to use the filler until all treatments end. It is recommended to use 0.5mm needle to prevent energy from going through the skin deeply in the event of a treatment within six months after injecting a filler.
A Botox
A Botox can freely be used before and after the treatment using INTRAcel.
A)Filler
It has no harm to inject a filler after treatment using INTRAcel, however, it can be harmful to take INTRAcel treatment after injecting a filler. Therefore it is recommended not to use the filler until all treatments end. It is recommended to use 0.5mm needle to prevent energy from going through the skin deeply in the event of a treatment within six months after injecting a filler.
A Botox
A Botox can freely be used before and after the treatment using INTRAcel.
2010년 6월 23일 수요일
Directions after the treatment using INTRAcel
Q) Directions after the treatment using INTRAcel
A) Do not wash off your face for a day and cool down treated parts with ice pack for about ten minutes.
Avoid having a sauna and swimming for a week and do not drink any alcohol for three days after the treatment.
Each time your face feels tight, apply moisturizer on the treated parts and every time you go out, wear a sunscreen.
2010년 6월 15일 화요일
2010년 6월 9일 수요일
intracel Article - Evaluation of the wound healing response post deep dermal heating by fractional RF: INTRAcel
intracel Article - Evaluation of the wound healing response post deep dermal heating by fractional RF: INTRAcel
Evaluation of the wound healing response post deep dermal heating by fractional RF: INTRAcelUn-Cheol .Yeo, M.D.
S&U Dermatologic Clinic, Seoul, KoreaBackground and Objectives: A new device, INTRACEL heating up deep dermis using microneedles of bipolar and monopolar RF in a minimally invasive way; Fractional Radiofrequency Microneedling (“FRM”) technology was introduced lately. This study was conducted to see the wound healing response following FRM treatment for both human and porcine skin.Study Design and Methods: A maximum power of 700W RF can be used on bipolar mode to deliver the thermal energy directly into the dermis. 49 microneedles are diffused to 1cm2 areas on its tip, and those needles are insulated except its distal 0.3mm to avoid the thermal damage on the skin surface when it penetrates into skin. 10 healthy patients and aseptically processed a micro-pig were involved in this clinical trial. Healing responses were observed by the time after FRM treatment at various energy levels. Biopsy was conducted to see the wound healing process immediately after the treatment, 2days, 14days, 28days, and 10 weeks post the treatment. H&E stain and HSP47 stain were conducted to see the changes in inflammatory cell, collagen. Also, the study has conducted RT-PCR with the tissue biopsied from Micro-pig covering 10 weeks to see mRNA change of collagen, Heat Shock Proteins (HSPs), and matrix metalloproteinase (MMPs).Results: No thermal damage was observed on the epidermis and upper dermis except the area the microneedle electrodes passed, but the collagen was damaged within the reticular dermis. Denatured collagen column was seen through H&E test. 10 weeks later, the observation clearly showed that the pattern of new collagen was granulated on the area of damaged collagen. The increases were observed in 70 days from the FRM treatment in various inflammatory cytokine, HSPs, procollagen 1, procollagen 3, tropoelastin, and fibrillin through RT-PCR test. Seeing the change due to the energy level used for the treatment, the tissue treated with high level energy showed increase of the number of fibroblast, and the collagen reproduction as well as the replacement of damaged collagen.Conclusion: FRM leaves minimal damage by its needle penetration on epidermis and upper dermis, and fractional deep dermal heating is possible in the lower dermis. Such damaged collagen is healed by new collagen being granulated as time passes, and fibroblast proliferation was seen. These conditions are well observed in RT-PCR results, as HSP expressions supporting the production of a new collagen in the tissue stained with HSP antibody. FRM treatment is expected to be good for a tightening, wrinkle reduction, and scar treatment, as it uses various needle depths with the different targets to induce the production of a new collagen and elastin.12th symposium of the Association of Korean Dermatologists (2009) 2Key words: bipolar; fractional; micro-needleelectrodes; neocollagenesis; neoelastogenesis;deep dermal heating; wound healing
INTRODUCTIONWhen ASR (Ablative Skin Resurfacing) was introduced to the aesthetic market, it was effective but it produced patients a lot of pain with a long down time. In contrast, NAR (Non-ablative Rejuvenation)’s side effects and pain was a lot lessthan ASR, but it provided insufficient efficacy to reach the patient’s satisfactory level. Later, fractional laser technology was introduced, but epidermis was burnt and left pigmentation when it tried to deliver the strong energy to deep skin layer.It was obvious as it uses epidermis as the passage of the thermal energy. The new bipolar microneedles RF device was invented to satisfy such demands and needs. This machine has microneedles and it delivers fractional RF energy to induce the thermal damage in the target area of the dermis. Fractional Radiofrequency Microneedling (FRMTM) makes thermally and partially injured columns in deep dermis. The dermis in between the thermally injured columns is not wounded. A histology, immunohistochemistry, and molecular biological studies are adopted to observe woundhealing process on human body and micro-pig. As results, we found out the fact that FRM treatment induces a strong wound healing response to collagen draw out and elastin remodeling by expressing HSPs and cytokines.
STUDY DESIGN AND METHODSA study was carried out total of 70 days with 10 subjects and micro-pig. Patients and micro-pig were treated and observed immediately after, 2 days, 14 days, 28 days, and 10 weeks later. The treatment had done prior to their prescheduled biopsy to capture the temporal evolution of the in vivo wound healing response.
FRM delivers bipolar RF into dermis by 49 microneedles electrodes of 1.5mm or 0.8mm in their length. Microneedles are inserted into skin at 90 degrees. RF is emitted to dermis after 0.2 seconds post the insertion of microneedles. Thedelivery times of RF energy are different by the energy level, and the lengths of needles could be chosen among 0.5, 0.8, 1.5, and 2.0mm.
Histological wound healing response was measured to determine deep dermal heating of collagen, elastin, and inflammation. Incision treatments were done for 2 different 2mm biopsies at each time points. The biopsied tissue was set in 10% neutral buffered formalin and moved into paraffin. 10 paraffin or sections were stained with H&E andHSP47 through serial section. Semi-quantitative reverse transcription chain reaction, RT-PCR is used to measure the changes in molecules of remodeling within the dermis post FRM treatment.
Electrophoresis was implemented after the RT-PCR. The densitometry analysis using AlphasEase software was used, and ß -actin, ß-globin glyceraldehyde-3-phosphate dehydrogenase was used as housekeeping genes. Amplicon intensity ratio was estimated by dividing the intensity of housekeeping gene with the intensity value for thegene of interest by the intensity value of for ß -actin.The study observed wound healing response in the human body and micro-pig by histology, immunohistochemistry, molecular biology technologies. Research findings indicate that FRM technology enables coagulation necrosis column to be developed in the dermis, and induced dramatic wound healing response, remarkable increase inHSP expression along with dynamical remodeling of collagen and elastin. Thus, this deep dermal fractional heating, FRM technology will be good for facial wrinkles, tightening and scar treatment.
Fig.1. FRM lesions post-treatment. Study adopted in vivo test on human skin immediately, 14 days, 10 weeks post FRM treatment. Observation indicates remodeling in the dermis for 10 weeks. Immediate postoperative shown as “(A)”, “(B)” is postoperative 14days, and “(C)” is postoperative 10weeks. The immediate postoperative shows a clear approval of deep dermal fractional heating without damage on the epidermis, and the density of collagen postoperative 10 weeks more increased than immediate postoperative. Every approval shows dermis remodeling and the progress of new collagen was being created. All images are H&E stained and shown at 2X the original magnification.
RESULTS AND CONCLUSIONDeep dermal fractional heatingTo see the change in the tissue after FRM treatment, biopsied tissue was stained by H&E immediate, 2days, 14days, 28 days, and 10 weeks post-treatments. Thermally damaged area was detected in reticular dermis immediately after FRM treatment (Fig.1A). Coagulation necrosis part is formed in the deep dermis. Collagen denatured area is disappearing gradually 14 days post-treatment (Fig.1B), and then replaced with a new collagen completely in 70 days post-treatment (Fig.1C). A connection of two coagulation columns with needles tracts on the epidermis were observed in the tissue by serial section just after the treatment (Fig.2).Collagen damage is repaired with time.An infiltration of inflammatory cells was seen to the time points. From postoperative 2 days post treatment slight permeation of inflammatory cells is seen (Fig.3A), partially damaged collagen is absorbed in 14 days and new collagen is seen (Fig.3B). Postoperative 28days, the proliferation of young fibroblast is observed (Fig.3C). Lesion isbeing replaced with new collagen in 70 days. HSP47 is expressed in the dermis between 28 days and 70days after the treatment unitedly with the response of inflammatory cells (Fig.4)The RT-PCR has been taken before the treatment and in the various time points to understand better on the results of molecule events arousing by FRM treatment. Research found that cytokine expression increase for 4 weeks stably but MMPs increased gradually. HSP47 increased over 3 times until 70 days and the expression level of extracellular matrix protein also continued to increase up to 5, 3 times before treatment in tropoelastin and procollagen cases (Table.1)Neo-collagenesis is correlated to degree of damage.This research shows the relationship between a new collagen production and energy level on damage, as the observation shows the increase of the fibroblast proliferation and HSP47 expression at the various energy levels. As the energy level increased, collagen production also increased along with the number of fibroblast (Fig.5). HSP47 also was expressed more in the higher level (Fig.6).
Fig.2. Immediate after FRM treatment. Coagulation columns were made that connected by the two electrodes of bipolar RF plus and minus being connected precisely.Fig.3. The amorphous degeneration. There is a minimal inflammation in the lesion in 2 days post-treatment (A). Mild infiltrate of chronic inflammatory cells are present in the lesion and adjacent perivascular spaces 14 days post treatment (B). The lesion got absorbed and appeared edematous. The irregular collagen tissue partially replaced to the degenerated lesion In 28 days post treatment (C). The lesion is almost replaced by collagen and was remarkably raised cell density in 70days post treatment (D). The image is seen at the 4X original magnification.
Fig.4. HSP47 responses to FRM treatment. The tissue of micro-pig was stained with HSP47 antibody post FRM treatment. (A) is immediately post treatment, (B) is 14 days post treatment, a minimum of HSP47 expression was detected in the dermis immediately post FRM treatment. HSP47 increases gradually (B), expressed between 28 days (C) and 10 weeks (D), and diffused causing the coagulation necrosis column to be well recovered.Biopsy showed that the number of the fibroblast didn’t increase in the low energy level, and only the hypertrophic response which can get fibers thicker. While fibroblast number increased in the higher energy showing hyperplastic response, an increase in cellularity. The number of cells increases during the wound healing, the effect continued a long time, in general.No change beyond the treatment depth.HSP47 expression area was observed to see the influence on the extension of collagen remodeling which can be caused by FRM treatment. The comparison of H&E and HSP47 stained tissue shows the occurrences of the strongest expression at the area of collagen denaturation. However, it wasn’t expressed any energy level in the deeper area (Fig.7). Therefore, it is better to try FRM to treat the target area when the lesion is in the deep area
Fig.5. Fig of micro-pig tissue 70 days post FRM treatment. Nucleus and fibers are increased more as energy level get higher.Fig.6. HSP47 response 70 days post FRM treatment. In fact, HSP47 expression is more than doubled in the higher energy level, which means high energy level causes the greater collagen composition.DISCUSSIONThe 10 weeks observation post FRM treatment has shown dermis remodeling process such as increased production of HSP47 and procollagen, and a full replacement of turning denatured collagen into a new collagen. The study proved the actual volume effect by showing increased production of procollagen and new elastin in the immunohistochemistry and RT-PCR. The result of FRM treatment is better when it operated with a high energy level if it doesn’t cause side effect and doesn’t make down time long as it produced moreFig.7. Responses of HSP47 to FRM treatment.HSP47 is expressed between denatured areas, but never expressed in the deep dermis deeper than the area treated before.collagen. Through the study, fractional deep dermal heating system on a selected target area is expected to provide good and positive efficacy for askin tightening, wrinkle reduction, scars and pore treatment.
Evaluation of the wound healing response post deep dermal heating by fractional RF: INTRAcelUn-Cheol .Yeo, M.D.
S&U Dermatologic Clinic, Seoul, KoreaBackground and Objectives: A new device, INTRACEL heating up deep dermis using microneedles of bipolar and monopolar RF in a minimally invasive way; Fractional Radiofrequency Microneedling (“FRM”) technology was introduced lately. This study was conducted to see the wound healing response following FRM treatment for both human and porcine skin.Study Design and Methods: A maximum power of 700W RF can be used on bipolar mode to deliver the thermal energy directly into the dermis. 49 microneedles are diffused to 1cm2 areas on its tip, and those needles are insulated except its distal 0.3mm to avoid the thermal damage on the skin surface when it penetrates into skin. 10 healthy patients and aseptically processed a micro-pig were involved in this clinical trial. Healing responses were observed by the time after FRM treatment at various energy levels. Biopsy was conducted to see the wound healing process immediately after the treatment, 2days, 14days, 28days, and 10 weeks post the treatment. H&E stain and HSP47 stain were conducted to see the changes in inflammatory cell, collagen. Also, the study has conducted RT-PCR with the tissue biopsied from Micro-pig covering 10 weeks to see mRNA change of collagen, Heat Shock Proteins (HSPs), and matrix metalloproteinase (MMPs).Results: No thermal damage was observed on the epidermis and upper dermis except the area the microneedle electrodes passed, but the collagen was damaged within the reticular dermis. Denatured collagen column was seen through H&E test. 10 weeks later, the observation clearly showed that the pattern of new collagen was granulated on the area of damaged collagen. The increases were observed in 70 days from the FRM treatment in various inflammatory cytokine, HSPs, procollagen 1, procollagen 3, tropoelastin, and fibrillin through RT-PCR test. Seeing the change due to the energy level used for the treatment, the tissue treated with high level energy showed increase of the number of fibroblast, and the collagen reproduction as well as the replacement of damaged collagen.Conclusion: FRM leaves minimal damage by its needle penetration on epidermis and upper dermis, and fractional deep dermal heating is possible in the lower dermis. Such damaged collagen is healed by new collagen being granulated as time passes, and fibroblast proliferation was seen. These conditions are well observed in RT-PCR results, as HSP expressions supporting the production of a new collagen in the tissue stained with HSP antibody. FRM treatment is expected to be good for a tightening, wrinkle reduction, and scar treatment, as it uses various needle depths with the different targets to induce the production of a new collagen and elastin.12th symposium of the Association of Korean Dermatologists (2009) 2Key words: bipolar; fractional; micro-needleelectrodes; neocollagenesis; neoelastogenesis;deep dermal heating; wound healing
INTRODUCTIONWhen ASR (Ablative Skin Resurfacing) was introduced to the aesthetic market, it was effective but it produced patients a lot of pain with a long down time. In contrast, NAR (Non-ablative Rejuvenation)’s side effects and pain was a lot lessthan ASR, but it provided insufficient efficacy to reach the patient’s satisfactory level. Later, fractional laser technology was introduced, but epidermis was burnt and left pigmentation when it tried to deliver the strong energy to deep skin layer.It was obvious as it uses epidermis as the passage of the thermal energy. The new bipolar microneedles RF device was invented to satisfy such demands and needs. This machine has microneedles and it delivers fractional RF energy to induce the thermal damage in the target area of the dermis. Fractional Radiofrequency Microneedling (FRMTM) makes thermally and partially injured columns in deep dermis. The dermis in between the thermally injured columns is not wounded. A histology, immunohistochemistry, and molecular biological studies are adopted to observe woundhealing process on human body and micro-pig. As results, we found out the fact that FRM treatment induces a strong wound healing response to collagen draw out and elastin remodeling by expressing HSPs and cytokines.
STUDY DESIGN AND METHODSA study was carried out total of 70 days with 10 subjects and micro-pig. Patients and micro-pig were treated and observed immediately after, 2 days, 14 days, 28 days, and 10 weeks later. The treatment had done prior to their prescheduled biopsy to capture the temporal evolution of the in vivo wound healing response.
FRM delivers bipolar RF into dermis by 49 microneedles electrodes of 1.5mm or 0.8mm in their length. Microneedles are inserted into skin at 90 degrees. RF is emitted to dermis after 0.2 seconds post the insertion of microneedles. Thedelivery times of RF energy are different by the energy level, and the lengths of needles could be chosen among 0.5, 0.8, 1.5, and 2.0mm.
Histological wound healing response was measured to determine deep dermal heating of collagen, elastin, and inflammation. Incision treatments were done for 2 different 2mm biopsies at each time points. The biopsied tissue was set in 10% neutral buffered formalin and moved into paraffin. 10 paraffin or sections were stained with H&E andHSP47 through serial section. Semi-quantitative reverse transcription chain reaction, RT-PCR is used to measure the changes in molecules of remodeling within the dermis post FRM treatment.
Electrophoresis was implemented after the RT-PCR. The densitometry analysis using AlphasEase software was used, and ß -actin, ß-globin glyceraldehyde-3-phosphate dehydrogenase was used as housekeeping genes. Amplicon intensity ratio was estimated by dividing the intensity of housekeeping gene with the intensity value for thegene of interest by the intensity value of for ß -actin.The study observed wound healing response in the human body and micro-pig by histology, immunohistochemistry, molecular biology technologies. Research findings indicate that FRM technology enables coagulation necrosis column to be developed in the dermis, and induced dramatic wound healing response, remarkable increase inHSP expression along with dynamical remodeling of collagen and elastin. Thus, this deep dermal fractional heating, FRM technology will be good for facial wrinkles, tightening and scar treatment.
Fig.1. FRM lesions post-treatment. Study adopted in vivo test on human skin immediately, 14 days, 10 weeks post FRM treatment. Observation indicates remodeling in the dermis for 10 weeks. Immediate postoperative shown as “(A)”, “(B)” is postoperative 14days, and “(C)” is postoperative 10weeks. The immediate postoperative shows a clear approval of deep dermal fractional heating without damage on the epidermis, and the density of collagen postoperative 10 weeks more increased than immediate postoperative. Every approval shows dermis remodeling and the progress of new collagen was being created. All images are H&E stained and shown at 2X the original magnification.
RESULTS AND CONCLUSIONDeep dermal fractional heatingTo see the change in the tissue after FRM treatment, biopsied tissue was stained by H&E immediate, 2days, 14days, 28 days, and 10 weeks post-treatments. Thermally damaged area was detected in reticular dermis immediately after FRM treatment (Fig.1A). Coagulation necrosis part is formed in the deep dermis. Collagen denatured area is disappearing gradually 14 days post-treatment (Fig.1B), and then replaced with a new collagen completely in 70 days post-treatment (Fig.1C). A connection of two coagulation columns with needles tracts on the epidermis were observed in the tissue by serial section just after the treatment (Fig.2).Collagen damage is repaired with time.An infiltration of inflammatory cells was seen to the time points. From postoperative 2 days post treatment slight permeation of inflammatory cells is seen (Fig.3A), partially damaged collagen is absorbed in 14 days and new collagen is seen (Fig.3B). Postoperative 28days, the proliferation of young fibroblast is observed (Fig.3C). Lesion isbeing replaced with new collagen in 70 days. HSP47 is expressed in the dermis between 28 days and 70days after the treatment unitedly with the response of inflammatory cells (Fig.4)The RT-PCR has been taken before the treatment and in the various time points to understand better on the results of molecule events arousing by FRM treatment. Research found that cytokine expression increase for 4 weeks stably but MMPs increased gradually. HSP47 increased over 3 times until 70 days and the expression level of extracellular matrix protein also continued to increase up to 5, 3 times before treatment in tropoelastin and procollagen cases (Table.1)Neo-collagenesis is correlated to degree of damage.This research shows the relationship between a new collagen production and energy level on damage, as the observation shows the increase of the fibroblast proliferation and HSP47 expression at the various energy levels. As the energy level increased, collagen production also increased along with the number of fibroblast (Fig.5). HSP47 also was expressed more in the higher level (Fig.6).
Fig.2. Immediate after FRM treatment. Coagulation columns were made that connected by the two electrodes of bipolar RF plus and minus being connected precisely.Fig.3. The amorphous degeneration. There is a minimal inflammation in the lesion in 2 days post-treatment (A). Mild infiltrate of chronic inflammatory cells are present in the lesion and adjacent perivascular spaces 14 days post treatment (B). The lesion got absorbed and appeared edematous. The irregular collagen tissue partially replaced to the degenerated lesion In 28 days post treatment (C). The lesion is almost replaced by collagen and was remarkably raised cell density in 70days post treatment (D). The image is seen at the 4X original magnification.
Fig.4. HSP47 responses to FRM treatment. The tissue of micro-pig was stained with HSP47 antibody post FRM treatment. (A) is immediately post treatment, (B) is 14 days post treatment, a minimum of HSP47 expression was detected in the dermis immediately post FRM treatment. HSP47 increases gradually (B), expressed between 28 days (C) and 10 weeks (D), and diffused causing the coagulation necrosis column to be well recovered.Biopsy showed that the number of the fibroblast didn’t increase in the low energy level, and only the hypertrophic response which can get fibers thicker. While fibroblast number increased in the higher energy showing hyperplastic response, an increase in cellularity. The number of cells increases during the wound healing, the effect continued a long time, in general.No change beyond the treatment depth.HSP47 expression area was observed to see the influence on the extension of collagen remodeling which can be caused by FRM treatment. The comparison of H&E and HSP47 stained tissue shows the occurrences of the strongest expression at the area of collagen denaturation. However, it wasn’t expressed any energy level in the deeper area (Fig.7). Therefore, it is better to try FRM to treat the target area when the lesion is in the deep area
Fig.5. Fig of micro-pig tissue 70 days post FRM treatment. Nucleus and fibers are increased more as energy level get higher.Fig.6. HSP47 response 70 days post FRM treatment. In fact, HSP47 expression is more than doubled in the higher energy level, which means high energy level causes the greater collagen composition.DISCUSSIONThe 10 weeks observation post FRM treatment has shown dermis remodeling process such as increased production of HSP47 and procollagen, and a full replacement of turning denatured collagen into a new collagen. The study proved the actual volume effect by showing increased production of procollagen and new elastin in the immunohistochemistry and RT-PCR. The result of FRM treatment is better when it operated with a high energy level if it doesn’t cause side effect and doesn’t make down time long as it produced moreFig.7. Responses of HSP47 to FRM treatment.HSP47 is expressed between denatured areas, but never expressed in the deep dermis deeper than the area treated before.collagen. Through the study, fractional deep dermal heating system on a selected target area is expected to provide good and positive efficacy for askin tightening, wrinkle reduction, scars and pore treatment.
2010년 6월 1일 화요일
2010년 5월 26일 수요일
2010년 5월 24일 월요일
2010년 5월 18일 화요일
intracel Article - The Clinical Efficacy and Statistical Evaluation of INTRAcel
intracel Article - The Clinical Efficacy and Statistical Evaluation of INTRAcel
[ flle download ]intracel Dr.Takashi article_091222_eng(final).pdf
The Clinical Efficacy and Statistical Evaluation of INTRAcel
TreatmentTakashi Takahashi, M.D.DermatologistTakahashi ClinicShibuya, Tokyo, Japan
Background:Minimally invasive Fractional Radiofrequency Microneedls(FRM) device is recently introduced. The device gives selective heating in the dermis using bipolar RF (or monopolar RF) through microneedles. This study is to demonstrate clinical improvement following FRM.
Methods:60 subjects with scar, facial laxity and large pore were enrolled. 60 patients were treated with a minimally-invasive FRM device (INTRAcel). Bipoloar RF energy was delivered through 49 micro-needle electrodes deployed into the reticular dermis from the papillary dermis vertically to the skin surface. Only subjects consenting to longitudinal follow-up during the study were enrolled to observe the improvement as time went by.
Results:As the result of 3 months follow-up, all patients did not have any problems during the period and any adverse events or complications weren’t observed. Patient satisfaction was high with 83.3%. Self-assessment of clinical outcome showed moderate to significant improvement in skin laxity, scar and pore.
Conclusion:Bipolar RF treatment makes deep dermal fractional heating in targeted deeper dermis. Clinical improvement by FRM treatment is related to collagen and elastin fiber which are generated by wound healing process.These results suggest Fractional Radiofrequency Microneedles treatment may become an important option for the treatment of facial skin laxity and scars.
INTRODUCTION
Previous generation ASR(Ablative Skin Resurfacing) laser devices were effective, but many of them could not avoid the problems of long down time and patient pain. On the contrary, NAR (Non-ablative Skin Rejuvenation) laser devices reduced pain and adverse effects, but these devices could not make dramatic effects. In the middle of 2000s, fractional technology opened new generation overcoming previous problems. But the fractional treatment was limitedly used because it could not control penetration depth and it gave damage on the epidermis.Recently introduced FRM opens new generation in aesthetic market by meeting the market demand. We observed wound healing process after the FRM treatment in the human body using histological and molecular biology technology. As the result, we found out the fact that FRM treatment induced a strong wound healing response drawing out collagen and elastin remodeling by Heat Shock Protein (HSPs) expression and various cytokines. Clinical improvement in skin laxity and acne scar is achieved by volume effects produced by neocollagenesis and neoelastogenesis.
STUDY DESIGN AND METHODSTUDY DESIGN
All subjects consented prior to participation. Patient consent for digital photography and adding the photos in article was also organized prior to treatment. Exclusion criteria consisted of history of injection with silicone, botox, filler, fat or a synthetic material placed in the intended treatment area, hypertrophic scar or bleeding disorder, lidocaine hypersensitivity, photosensitivity or anaphylaxis. Patients with a compromised immune system impaired wound healing, collagen vascular disease, implantable electronic device, or active infection were disqualified from participation. Only subjects consenting to longitudinal follow-up during the study were enrolled.
CLINICAL PROCEDURE
Patients were treated with a minimally-invasive FRM device. Bipolar RF energy was delivered through 49 micro-needle electrodes deployed into the reticular dermis vertically to the skin surface. The epidermis and superficial dermis were protected securely from RF heating at the insertion location by insulating the rest of each electrodes except its distal 0.3mm. Standardized photographs were taken at the baseline and at 3-month follow-up. Follow-up patients were asked to rate their overall satisfaction, the impression of scars and laxity improvement using a five-point scale.TREATMENT RESULTS60 subjects with mild to significant scar and rhytids were enrolled. All patients received one FRM full face treatment. All subjects were managed for 3 month follow-up. Mean age was 41.2 +/-23.5 years.All patients experienced transient edema and erythema, but it resolved within 48 hours. 13.3% of the patients experienced dry skin. However it was gone away within 2 weeks. Patient satisfaction was high with 1.6% dissatisfied, 15% neutral, 0% satisfied and 83.3% very satisfied (Fig 1). FRM treatment self assessment of clinical outcome showed significant improvement in acne scar and moderate to significant improvement in skin laxity.
CONCLUSIONFRM treatment has been shown to provide consistent and meaningful improvement in facial scar and laxity without complications and adverse effects. In this study, the average improvement seen following a single FRM treatment was approximately 93.3%. The result of this study may become an important option for scar and facial laxity treatment.
[ flle download ]intracel Dr.Takashi article_091222_eng(final).pdf
[ flle download ]intracel Dr.Takashi article_091222_eng(final).pdf
The Clinical Efficacy and Statistical Evaluation of INTRAcel
TreatmentTakashi Takahashi, M.D.DermatologistTakahashi ClinicShibuya, Tokyo, Japan
Background:Minimally invasive Fractional Radiofrequency Microneedls(FRM) device is recently introduced. The device gives selective heating in the dermis using bipolar RF (or monopolar RF) through microneedles. This study is to demonstrate clinical improvement following FRM.
Methods:60 subjects with scar, facial laxity and large pore were enrolled. 60 patients were treated with a minimally-invasive FRM device (INTRAcel). Bipoloar RF energy was delivered through 49 micro-needle electrodes deployed into the reticular dermis from the papillary dermis vertically to the skin surface. Only subjects consenting to longitudinal follow-up during the study were enrolled to observe the improvement as time went by.
Results:As the result of 3 months follow-up, all patients did not have any problems during the period and any adverse events or complications weren’t observed. Patient satisfaction was high with 83.3%. Self-assessment of clinical outcome showed moderate to significant improvement in skin laxity, scar and pore.
Conclusion:Bipolar RF treatment makes deep dermal fractional heating in targeted deeper dermis. Clinical improvement by FRM treatment is related to collagen and elastin fiber which are generated by wound healing process.These results suggest Fractional Radiofrequency Microneedles treatment may become an important option for the treatment of facial skin laxity and scars.
INTRODUCTION
Previous generation ASR(Ablative Skin Resurfacing) laser devices were effective, but many of them could not avoid the problems of long down time and patient pain. On the contrary, NAR (Non-ablative Skin Rejuvenation) laser devices reduced pain and adverse effects, but these devices could not make dramatic effects. In the middle of 2000s, fractional technology opened new generation overcoming previous problems. But the fractional treatment was limitedly used because it could not control penetration depth and it gave damage on the epidermis.Recently introduced FRM opens new generation in aesthetic market by meeting the market demand. We observed wound healing process after the FRM treatment in the human body using histological and molecular biology technology. As the result, we found out the fact that FRM treatment induced a strong wound healing response drawing out collagen and elastin remodeling by Heat Shock Protein (HSPs) expression and various cytokines. Clinical improvement in skin laxity and acne scar is achieved by volume effects produced by neocollagenesis and neoelastogenesis.
STUDY DESIGN AND METHODSTUDY DESIGN
All subjects consented prior to participation. Patient consent for digital photography and adding the photos in article was also organized prior to treatment. Exclusion criteria consisted of history of injection with silicone, botox, filler, fat or a synthetic material placed in the intended treatment area, hypertrophic scar or bleeding disorder, lidocaine hypersensitivity, photosensitivity or anaphylaxis. Patients with a compromised immune system impaired wound healing, collagen vascular disease, implantable electronic device, or active infection were disqualified from participation. Only subjects consenting to longitudinal follow-up during the study were enrolled.
CLINICAL PROCEDURE
Patients were treated with a minimally-invasive FRM device. Bipolar RF energy was delivered through 49 micro-needle electrodes deployed into the reticular dermis vertically to the skin surface. The epidermis and superficial dermis were protected securely from RF heating at the insertion location by insulating the rest of each electrodes except its distal 0.3mm. Standardized photographs were taken at the baseline and at 3-month follow-up. Follow-up patients were asked to rate their overall satisfaction, the impression of scars and laxity improvement using a five-point scale.TREATMENT RESULTS60 subjects with mild to significant scar and rhytids were enrolled. All patients received one FRM full face treatment. All subjects were managed for 3 month follow-up. Mean age was 41.2 +/-23.5 years.All patients experienced transient edema and erythema, but it resolved within 48 hours. 13.3% of the patients experienced dry skin. However it was gone away within 2 weeks. Patient satisfaction was high with 1.6% dissatisfied, 15% neutral, 0% satisfied and 83.3% very satisfied (Fig 1). FRM treatment self assessment of clinical outcome showed significant improvement in acne scar and moderate to significant improvement in skin laxity.
CONCLUSIONFRM treatment has been shown to provide consistent and meaningful improvement in facial scar and laxity without complications and adverse effects. In this study, the average improvement seen following a single FRM treatment was approximately 93.3%. The result of this study may become an important option for scar and facial laxity treatment.
[ flle download ]intracel Dr.Takashi article_091222_eng(final).pdf
intracel application
intracel application
A high pressure RF emitted momentary on acne scar, burn scar, operation scar, traumatic scar and chapped skin regenerates skin.
Many people squeeze acne habitually to avoid it becoming a spot. However, fiddling with acne makes it inflamed and severe. What the worse thing is, patient can suffer from pain and pus come out of it. In this case, it takes long time to repair and could leave acne scar like craters on the moon If distressed woman from acne scar wears heavy make-up, it can make skin trouble even severe, therefore, applying ointment might be needed. But overused ointment can expand capillaries and make skin too sensitive to environments. Not only a scar but also a flush on face can disturb a daily life.
Skin often chaps easily on your shoulders, belly, thighs ,calves and even hips in case of gaining weight rapidly such as period of growth and pregnancy or applying steroid ointment on delicate skin for a long time. Once skin chaps, quick treatment will get good results.
Wrinkles are lines which form on a skin as dermis loose it’s collagen fiber. The appearances of the wrinkles are different slightly according to it’s location. Beside the small wrinkles which appear as aging, there are many wrinkles can appear on face and body because of gravity, folding a skin and making expressions. And each of them has it’s own treatment as per it’s cause and depth.
There are over 20 thousand pores on a face. Generally the diameter of a pore is approximately 0.02~0.05mm ,therefore, it’s difficult to see a pore for yourself. However, something like aging, change of seasons, woman’s menstrual cycle , pregnancy, stress can promote the production of sebum and then pores become as large as we can see. Many people have the misconception that a pore emits sweat but sweat comes out from sweat gland, through the skin. Large pores not only look dirty and oily but also can generate troubles on the skin by making it easy for gems to come in. In conclusion, the most important thing is to protect pores from expansion.
Whitening is not making skin to be white, but helping skin texture to be bright and transparent by making freckles and facial blemishes lightly and removing callus from epidermis.Interface controls the pigmentation of skin and effects on skin texture to be bright and clear.
Pigmentation means uneven condition of a skin texture like strains. Usually pigmentation is caused by freckles, acne scar, etc.
Many people squeeze acne habitually to avoid it becoming a spot. However, fiddling with acne makes it inflamed and severe.What the worse thing is, patient can suffer from pain and pus come out of it.In this case, it takes long time to repair and could leave acne scar like craters on the moon If distressed woman from acne scar wears heavy make-up, it can make skin trouble even severe, therefore, applying ointment might be needed.But overused ointment can expand capillaries and make skin too sensitive to environments. Not only a scar but also a flush on face can disturb a daily life. Skin often chaps easily on your shoulders, belly, thighs ,calves and even hips in case of gaining weight rapidly such as period of growth and pregnancy or applying steroid ointment on delicate skin for a long time. Once skin chaps, quick treatment will get good results.
intracel application
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intracel - about intracel laser
intracel - about intracel laser
An old generation of ASR (Ablative Skin Resurfacing) has been effective, however it produced a lot of pain and a long down time to patients. On the other hand, NAR (Non-ablative Skin Rejuvenation) has reduced its side effect and pain, but then it was insufficient to produce a satisfactory level of efficacy.
Around in the middle of 2000s, Fractional technology has opened a new generation of the laser treatment to overcome the previous weaknesses. But still, that was also incapable of overcoming those limitations because if its penetration depth and destroying of epidermis.
After all of that experience, the 5th generation of new Intra-Cell RejuvenationSM , INTRACELTM Workstation turns customers need and wants into reality by its unique technology named “Fractional RF MicroneedleTM.“
Around in the middle of 2000s, Fractional technology has opened a new generation of the laser treatment to overcome the previous weaknesses. But still, that was also incapable of overcoming those limitations because if its penetration depth and destroying of epidermis.
After all of that experience, the 5th generation of new Intra-Cell RejuvenationSM , INTRACELTM Workstation turns customers need and wants into reality by its unique technology named “Fractional RF MicroneedleTM.“
Patented FRM (Fractional RF Microneedle) TechnologyTM is a unique technique to treat the target area by the fast penetration of a specially designed compound numbers of insulated micro-needles without a destruction of epidermis. Microneedles makes column for healing and simultaneously emitting a high-tensioned RF pulse on the target tissue inside the skin. Intracel microneedles directly in and out of the skin, and makes regularly arranged depth of destruction column which helps less pain and fast recovery .
The treatment would response to scar, wrinkle, Melasma, and freckles treatment at once. - No crust after the treatment as it is different from the deep skin laser peeling- No burden of care after the treatment - Cosmetic make up is possible - Short treatment time and down time.- Good results with patients of old age.- Applicable with no worries to the wide areas such as abdomen or the fleshy inside of the thigh.- Low risk of flush up or pigmentation compare with peeling or other laser treatment.- Hygienic as it uses a disposable tip
The treatment would response to scar, wrinkle, Melasma, and freckles treatment at once. - No crust after the treatment as it is different from the deep skin laser peeling- No burden of care after the treatment - Cosmetic make up is possible - Short treatment time and down time.- Good results with patients of old age.- Applicable with no worries to the wide areas such as abdomen or the fleshy inside of the thigh.- Low risk of flush up or pigmentation compare with peeling or other laser treatment.- Hygienic as it uses a disposable tip
intracel - about intracel laser
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